Physical Properties of Composite Bone Grafts Consisting of Calcium Phosphate Cement and Chondroitin Sulfate (Poster)

Published

April 1, 2005

Author(s)

Francis W. Wang, S Hirayama, James H. Yen, Shozo Takagi

Abstract

Calcium phosphate cement (CPC), consisting of tetracalcium phosphate (TTCP) and dicalcium phosphate anhydrous (DCPA), sets by reacting with water to form hydroxyapatite (HA). Aqueous polymer solutions also have been used with CPC powder to form composite bone grafts. The addition of a water-soluble polymer to CPC will reduce HA that needs to be replaced by bone tissues. Furthermore, the dissolution of the polymer creates pores that could promote the migration of bone cells into the composite bone grafts.We have measured the physical properties of composite bone grafts consisting of calcium phosphate cement and chondroitin sulfate. While the setting time, the conversion to hydroxyapatite, and the mechanical properties of the grafts were affected by chondroitin sulfate, the degradation of these performance properties was not dramatic and can be considered a worthwhile trade off in making the grafts capable of more rapid resorption and promoting the migration of bone cells into the grafts.

Citation

Society for Biomaterials

Pub Type

Journals

Keywords

bone grafts, calcium phosphate cement, chondroitin sulfate, composites, hydroxyapatite formation, mechanical properties, setting time

Citation

Wang, F. , Hirayama, S. , Yen, J. and Takagi, S. (2005), Physical Properties of Composite Bone Grafts Consisting of Calcium Phosphate Cement and Chondroitin Sulfate (Poster), Society for Biomaterials (Accessed November 6, 2025)