Parallel Synthesis and Dissolution Testing of Polyanhydride Random Copolymers
Brandon M. Vogel, Naomi Eidelman, Balaji Narasimhan, Surya Mallapragada
A linearly varying compositional library of 100 different polyanhydride randomcopolymers was designed, fabricated, and characterized within a few hours. A subset of this library was chosen and a substrate was designed and fabricated to enable the synthesis and monitoring of dye dissolution from a range of polyanhydride copolymers, in a parallel fashion, using a CCD camera. Multi-sample substrates were fabricated with a novel rapid prototyping method that consists of an (organic-solvent resistant) array of 10 10 microwells of 2 l volume each. The libraries were deposited with a custom-builtliquid dispensing system, consisting of a series of computer-controlled volumedispensing pumps and XYZ motion stages. Copolymers of 1,6-bis(p-carboxyphenoxy) hexane (CPH) and sebacic anhydride (SA) were characterized with infrared microspectroscopy to determine the composition within a well. Themethodology described in this work is amenable to numerous applications in the arenas of high-throughput polymer synthesis and characterization.
biodegradable, combinatorial, drug delivery, high-throughput, parallel synthesis, polyanhydride, rapid prototyping
, Eidelman, N.
, Narasimhan, B.
and Mallapragada, S.
Parallel Synthesis and Dissolution Testing of Polyanhydride Random Copolymers, Journal of the American Chemical Society, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=852486
(Accessed December 1, 2023)