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Optical hyperpolarization and NMR detection of 129Xe on a microfluidic chip



Ricardo Jimenez Martinez, Daniel J. Kennedy, Michael Rosenbluh, Elizabeth A. Donley, Svenja A. Knappe, Scott J. Seltzer, Hattie L. Ring, Vikram S. Bajaj, John E. Kitching


We present a microfluidic chip that enables the production of laser-polarized 129Xe gas and its optical detection. Production of polarized 129Xe and its remote detection is achieved under flowing gas conditions at low magnetic fields in two separate chambers connected by a microfluidic channel. Polarization of 129Xe occurs, through spin-exchange collisions with 87Rb atoms, in a 25 υL chamber using a few mW of pumping light. The polarized 129Xe atoms are detected in the second chamber using a 87Rb magnetometer. Using this device, under a total gas flow of 10 υL/sec, we have achieved 0.002 129Xe polarization fractions with a coherence time of about 1 second, and its efficient transport between both chambers. These results show that the miniaturization of 129Xe polarizers and its integration with sensitive detectors can be achieved without compromising polarization and sensitivity. They represent a first step towards the implementation of fully integrated 129Xe enhanced NMR instrumentation in low-cost, portable, and sensitive devices.
Nature Communications


hyperpolarizer, Laser spectroscopy, Noble gas, Nuclear magnetic resonance spectroscopy, Optical magnetometry, Optical pumping
Created May 20, 2014, Updated February 19, 2017