Wolf, C.
, Dalgliesh, R.
, de Campo, L.
, Smith, G.
and Weigandt, K.
(2025),
Multi-Scale Phase Separation in Poly(D,L-Lactide-co-glycolide) and Palmitic Acid Blends using Neutron and X-ray Scattering, Soft Matter, [online], https://doi.org/10.1039/D4SM01367K, https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=958968
(Accessed October 27, 2025)
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Multi-Scale Phase Separation in Poly(D,L-Lactide-co-glycolide) and Palmitic Acid Blends using Neutron and X-ray Scattering
Published
Author(s)
, Robert Dalgliesh, Liliana de Campo, Gregory N. Smith,
Abstract
In this work neutron and X-ray scattering are used to quantitatively characterize multi-scale phase separation in a model blend of poly(D,L-lactide-co-glycolide) or poly(D,L-lactide), both synthetic biodegradable polymers, and palmitic acid. We find that phase separation occurs on two different length scales from tens of nanometers to microns. Moreover, the large-scale phase separation mechanism is sensitive to the lactide to glycolide ratio of the polymer matrix and can limit the growth of nanoscale domains of the dispersed palmitic acid. The multiscale structure in these composite materials is directly tied to function in pharmaceutical applications where phase separation and small molecule crystallization are factors that determine controlled release behaviors and drug efficacy.Citation
Soft Matter
Volume
21
Issue
18
Pub Type
Journals
Download Paper
Keywords
polymer blends, amorphous solid dispersions, neutron scattering, X-ray scattering
Citation
Issues
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Created May 14, 2025, Updated July 22, 2025