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MILLIGRAM MASS METROLOGY FOR QUANTITATIVE DEPOSITION OF LIQUID SAMPLES

Published

Author(s)

Gordon A. Shaw

Abstract

Quantitative dispensing of liquids by mass becomes increasingly difficult as sample volume decreases. Whereas milliliter quantities of liquid can be directly weighed as dispensed on an analytical balance or using pycnometer methods, microliter samples are more challenging due to their milligram-scale mass and rapid evaporation. Here, a method for quantitative determination of the mass of 1 mm3 droplets of liquid is proposed. The weighing of a microcapillary pycnometer combined with traceable calibration masses and corrections for sample evaporation allows determination of the droplet mass of approximately 1 milligram with combined expanded uncertainty of 0.2 %.
Citation
Measurement: Sensors
Volume
22

Keywords

mass, milligram, liter, microliter, true becquerel, metrology

Citation

Shaw, G. (2022), MILLIGRAM MASS METROLOGY FOR QUANTITATIVE DEPOSITION OF LIQUID SAMPLES, Measurement: Sensors, [online], https://doi.org/10.1016/j.measen.2022.100380, https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=932337 (Accessed April 13, 2024)
Created May 22, 2022, Updated November 29, 2022