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MEASUREMENT OF DNA REPAIR PROTEINS IN RELATION TO DISEASE BIOMARKERS AND DRUG DEVELOPMENT

Published

Author(s)

Erdem Coskun, Pawel Jaruga, Leona D. Scanlan, Alessandro Tona, Mark S. Lowenthal, Prasad T. Reddy, M Miral Dizdar, Ann-Sofie Jemth, Olga Loseva, Thomas Helleday

Abstract

Introduction: In aerobic organisms, intracellular metabolism and exogenous sources such as ionizing radiation and carcinogenic compounds generate reactive species including free radicals derived from either oxygen or nitrogen. Oxidative stress thereby generated may lead to increased genetic instability, proliferation, cell death, apoptosis and onset of inflammation; a hallmark of cancer. Oxidatively induced DNA damage is repaired in vivo by various mechanisms involving numerous DNA repair proteins. If not repaired, this may lead to mutagenesis, which is a fundamental part of the molecular basis of all cancers. In addition, use of repair protein inhibitors in chemotherapy as the novel treatment strategy increases the importance of our knowledge for expressions of those proteins in human tissues.
Conference Dates
November 7-10, 2015
Conference Location
Natal
Conference Title
9th Congress of Toxicology in Developing Countries

Keywords

DNA repair proteins, biomarkers, LC-MS/MS

Citation

Coskun, E. , Jaruga, P. , Scanlan, L. , Tona, A. , Lowenthal, M. , Reddy, P. , , M. , Jemth, A. , Loseva, O. and Helleday, T. (2015), MEASUREMENT OF DNA REPAIR PROTEINS IN RELATION TO DISEASE BIOMARKERS AND DRUG DEVELOPMENT, 9th Congress of Toxicology in Developing Countries, Natal, -1 (Accessed May 26, 2024)

Issues

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Created November 7, 2015, Updated January 27, 2020