Measurement of the δ34S value in methionine by double spike multi-collector thermal ionization mass spectrometry using Carius tube digestion

Published

May 12, 2010

Author(s)

Jacqueline L. Mann, William R. Kelly

Abstract

Methionine is an essential amino acid and is the primary source of sulfur for humans. Using the double spike (33S-36S) multi-collector thermal ionization mass spectrometry (MC-TIMS) technique, three sample bottles of a methionine material obtained from the Institute for Reference Materials and Measurements have been measured for d34S and sulfur concentration. The mean d34S value, relative to Vienna Canyon Diablo Troilite (VCDT), determined was 10.34 +/- 0.11 per mil (n=9) with the uncertainty reported as expanded uncertainties (U). These d34S measurements include a correction for blank which has been previously ignored in studies of sulfur isotopic composition. The sulfur concentrations for the three bottles range from 56 to 88 micrograms/gram. The isotope composition and concentration results demonstrate the high accuracy and precision of the DS-MC-TIMS technique for measuring sulfur in methionine.

Citation

Rapid Communications in Mass Spectrometry

Volume

24

Pub Type

Journals

Download Paper

https://doi.org/10.1002/rcm.4686

Local Download

Keywords

sulfur isotope, TIMS, double spike, methionine, d34S

Citation

Mann, J. and Kelly, W. (2010), Measurement of the δ34S value in methionine by double spike multi-collector thermal ionization mass spectrometry using Carius tube digestion, Rapid Communications in Mass Spectrometry, [online], https://doi.org/10.1002/rcm.4686, https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=905222 (Accessed October 9, 2025)