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Maturation Stage Dependent Interaction of Mature Osteoblasts and Osteoprogenitor Cells with Microvascular Endothelial Cells

Published

Author(s)

Erica Takai, Rocky Tuan, Steven D. Hudson

Abstract

Angiogenesis is essential to the development, maintenance, and repair of bone tissue, as well as the survival of engineered tissues. Also, since osteoblasts (OB) are found in close proximity to endothelial cells in areas of new bone formation, it has been postulated that communication exists between these cell populations. Indeed, recent in vitro studies have shown that endothelial cells produce growth factors for OBs. In turn, OBs and osteoprogenitors have been found to produce angiogenic factors, while mature OBs also produce anti-angiogenic factors, suggesting that OBs are capable of modulating angiogenesis in bone in a maturation dependent manner. However, the cellular mechanisms behind OB-endothelial cell interactions during angiogenesis and bone formation remain unclear, particularly the influence of OB maturation.
Proceedings Title
Annual Meeting of the Orthopaedic Research Society | 53rd | | Orthopaedic Research Society
Conference Dates
February 11-14, 2007
Conference Location
San Diego, CA
Conference Title
Transactions of Annual Meeting of the Orthopaedic Research Society

Keywords

co-culture, endothelial cell, osteoblast, transwell

Citation

Takai, E. , Tuan, R. and Hudson, S. (2007), Maturation Stage Dependent Interaction of Mature Osteoblasts and Osteoprogenitor Cells with Microvascular Endothelial Cells, Annual Meeting of the Orthopaedic Research Society | 53rd | | Orthopaedic Research Society, San Diego, CA, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=852663 (Accessed March 3, 2024)
Created February 14, 2007, Updated February 19, 2017