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Marked Mitochondrial DNA Sequence Heterogeneity in Single CD34(+) Cell Clones From Normal Adult Bone Marrow

Published

Author(s)

M G. Shin, S Kajigaya, J P. McCoy, Barbara C. Levin, N S. Young

Abstract

Unexpected and marked heterogeneity in mitochondrial DNA sequence of individual CD34+ cells from normal adult bone marrow, not presetn in CD34+ cells from umbilical cord blood, indicates that age-related homoplasmic resolution of mtDNA mutations occurs in an actively replicating tissue. This research has important implications for forensic identifications and anthropological studies, hematopoietic stem cell biology and the measurement of the mtDNA mutation rate in mammalian cells.
Citation
Blood
Volume
103
Issue
2

Keywords

Bone marrow, clones, cord blood cells heterogeneity human, mitochondrial DNA

Citation

Shin, M. , Kajigaya, S. , McCoy, J. , Levin, B. and Young, N. (2004), Marked Mitochondrial DNA Sequence Heterogeneity in Single CD34(+) Cell Clones From Normal Adult Bone Marrow, Blood (Accessed July 13, 2024)

Issues

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Created January 14, 2004, Updated October 12, 2021