Skip to main content
U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Investigations into the potential contribution of a thermal mechanism for pulsed-high intensity focused ultrasound mediated delivery

Published

Author(s)

Brian E. O'Neill, Howard Vo, Mary Angstadt, Victor Frenkel, Bradford Wood, Timothy P. Quinn

Abstract

The mechanism behind pulsed high intensity focused ultrasound (pHIFU) effects leading to increased drug delivery are currently poorly understood. In this work, the thermal dose and peak temperatures associated with a typical pHIFU treatment were measured in mouse muscle. A non-ultrasonic hyperthermia (HT) treatment was then applied, designed to mimic the thermal component of the pHIFU treatment. The delivery of 200nm fluorescent nanoparticles was measured as a surrogate marker for drug delivery by pHIFU and HT treatments. Only the pHIFU treatment showed a significant increase in particle delivery.
Conference Dates
October 28-31, 2007
Conference Location
New York, NY, USA
Conference Title
2007 IEEE Int'l. Ultrasonic Symposium

Keywords

drug delivery, high intensity focused ultrasound, hyperthermia, thermal mechanism

Citation

O'Neill, B. , Vo, H. , Angstadt, M. , Frenkel, V. , Wood, B. and Quinn, T. (2007), Investigations into the potential contribution of a thermal mechanism for pulsed-high intensity focused ultrasound mediated delivery, 2007 IEEE Int'l. Ultrasonic Symposium, New York, NY, USA, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=50632 (Accessed April 12, 2024)
Created December 2, 2007, Updated October 12, 2021