O'Neill, B.
, Vo, H.
, Angstadt, M.
, Frenkel, V.
, Wood, B.
and Quinn, T.
(2007),
Investigations into the potential contribution of a thermal mechanism for pulsed-high intensity focused ultrasound mediated delivery, 2007 IEEE Int'l. Ultrasonic Symposium, New York, NY, USA, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=50632
(Accessed October 9, 2025)
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Investigations into the potential contribution of a thermal mechanism for pulsed-high intensity focused ultrasound mediated delivery
Published
Author(s)
Brian E. O'Neill, Howard Vo, Mary Angstadt, Victor Frenkel, Bradford Wood,
Abstract
The mechanism behind pulsed high intensity focused ultrasound (pHIFU) effects leading to increased drug delivery are currently poorly understood. In this work, the thermal dose and peak temperatures associated with a typical pHIFU treatment were measured in mouse muscle. A non-ultrasonic hyperthermia (HT) treatment was then applied, designed to mimic the thermal component of the pHIFU treatment. The delivery of 200nm fluorescent nanoparticles was measured as a surrogate marker for drug delivery by pHIFU and HT treatments. Only the pHIFU treatment showed a significant increase in particle delivery.Conference Dates
October 28-31, 2007
Conference Location
New York, NY, USA
Conference Title
2007 IEEE Int'l. Ultrasonic Symposium
Pub Type
Conferences
Download Paper
Keywords
drug delivery, high intensity focused ultrasound, hyperthermia, thermal mechanism
Citation
Issues
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Created December 2, 2007, Updated October 12, 2021