Intramolecular Structure and Dynamics in Computationally Designed Peptide-Based Polymers Displaying Tunable Chain Stiffness
Nairiti Sinha, Yi Shi, Christopher J. Kloxin, Jeffery G. Saven, Antonio Faraone, Grethe V. Jensen, Darrin J. Pochan
Polymers constructed via hybrid physical-covalent assembly of computationally designed peptide coiled coils, or bundlemers, display tunable chain stiffness via control of inter-bundlemer connectivity. Neutron spin echo spectroscopy reveals that rigid rod polymers of bundlemers possess a dynamic decay rate Γ Q2 behavior over the entire accessible probed range of wave vector, Q, whereas the semi-rigid chains with small flexible linkers exhibit distinct bending modes (Γ Q8/3) at intermediate-Q. Identical Γ Q2 behavior at high Q is indicative of similar, local bundlemer dynamics in both polymer systems.
, Shi, Y.
, Kloxin, C.
, Saven, J.
, Faraone, A.
, Jensen, G.
and Pochan, D.
Intramolecular Structure and Dynamics in Computationally Designed Peptide-Based Polymers Displaying Tunable Chain Stiffness, Physical Review Materials
(Accessed December 3, 2023)