NOTICE: Due to a lapse in annual appropriations, most of this website is not being updated. Learn more.
Form submissions will still be accepted but will not receive responses at this time. Sections of this site for programs using non-appropriated funds (such as NVLAP) or those that are excepted from the shutdown (such as CHIPS and NVD) will continue to be updated.
An official website of the United States government
Here’s how you know
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
Inter- and Intergenerational Transmission of a Human Mitochondrial DNA Heteroplasmy Among 13 Maternally-Related Individuals and Differences Between and Within Tissues in Two Family Members
Published
Author(s)
Koji Sekiguchi, K Kasai, Barbara C. Levin
Abstract
The transmission of a C16,291C/T heteroplasmy in the HV1 region of human mitochondrial DNA (mtDNA) was examined in buccal cells from 13 maternally-related individuals across three generations and in additional tissues (hair, blood or finger nails) from three members of this family. The ratio of C:T showed wide intra- and intergenerational variation as well as tissue variation within individuals. The results demonstrate that one or two sequence differences between samples in the mtDNA does not warrant an exclusion. To avoid false exclusions especially when comparing mtDNA from hair samples, we recommended the analysis of as many samples as possible in order to minimize the possibility that the detection of a rare polymorphism in a single sample would be considered an exclusion when it is really a match. The observation that the transmission of a mtDNA heteroplasmy.
Sekiguchi, K.
, Kasai, K.
and Levin, B.
(2003),
Inter- and Intergenerational Transmission of a Human Mitochondrial DNA Heteroplasmy Among 13 Maternally-Related Individuals and Differences Between and Within Tissues in Two Family Members, Mitochondrion
(Accessed October 14, 2025)