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Immunomodulatory Effects of Macrolide Antibiotics in Sulfur Mustard Exposed Airway Epithelial Cells: Quantum Dots-Mediated Immunocytochemical Analysis of iNOS and Diaminofluorescein-Mediated Flow Cytometric Analysis of Intracellular Nitric Oxide

Published

Author(s)

X P. Gao, Radharaman Ray, Yan Xiao, Peter E. Barker, Prabhati Ray

Abstract

Exposure of airway epithelial cells to 100 uM sulfur mustard significantly upregulated induced nitric oxide (iNOS) in cells. This response, quantitated by both flow cytometry and quantum dot-visualized antibodies, is returned to normal iNOS levels if cells are pretreated with FDA-approved macrolide antibiotics roxithromycin, azithromycin, clarithromycin and erythromycin.
Citation
Journal of Histochemistry & Cytochemistry

Keywords

macrolide antibotics, quantum dot fluorophores, sulfur mustard

Citation

Gao, X. , Ray, R. , Xiao, Y. , Barker, P. and Ray, P. (2021), Immunomodulatory Effects of Macrolide Antibiotics in Sulfur Mustard Exposed Airway Epithelial Cells: Quantum Dots-Mediated Immunocytochemical Analysis of iNOS and Diaminofluorescein-Mediated Flow Cytometric Analysis of Intracellular Nitric Oxide, Journal of Histochemistry & Cytochemistry (Accessed December 1, 2023)
Created October 12, 2021