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Identification of a Highly-Specific Hydroxyapatite-Binding Peptide Using Phage Display



Matthew Becker, Marc Roy, Scott K. Stanley, Eric J. Amis


Using a phage display approach we have identified a peptide sequence SVSVGMKPSPRP that selectively recognizes HA over amorphous calcium phosphate. Exploitation of the recognition properties of such peptidic species to specific polymorphs deposited during mineralization processes and in hydroxyapatite (HA)-derivatized composites may be useful in future studies for monitoring the progression of mineralization and potentially cell differentiation in situ as opposed to destructive endpoint measurements.
Advanced Materials


biomineralization, hydroxyapatite, phage display, quartz crystal microbalance, tooth


Becker, M. , Roy, M. , Stanley, S. and Amis, E. (2008), Identification of a Highly-Specific Hydroxyapatite-Binding Peptide Using Phage Display, Advanced Materials (Accessed May 21, 2024)


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Created May 19, 2008, Updated February 19, 2017