Skip to main content
U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Identification of a Highly-Specific Hydroxyapatite-Binding Peptide Using Phage Display

Published

Author(s)

Matthew Becker, Marc Roy, Scott K. Stanley, Eric J. Amis

Abstract

Using a phage display approach we have identified a peptide sequence SVSVGMKPSPRP that selectively recognizes HA over amorphous calcium phosphate. Exploitation of the recognition properties of such peptidic species to specific polymorphs deposited during mineralization processes and in hydroxyapatite (HA)-derivatized composites may be useful in future studies for monitoring the progression of mineralization and potentially cell differentiation in situ as opposed to destructive endpoint measurements.
Citation
Advanced Materials

Keywords

biomineralization, hydroxyapatite, phage display, quartz crystal microbalance, tooth

Citation

Becker, M. , Roy, M. , Stanley, S. and Amis, E. (2008), Identification of a Highly-Specific Hydroxyapatite-Binding Peptide Using Phage Display, Advanced Materials (Accessed May 21, 2024)

Issues

If you have any questions about this publication or are having problems accessing it, please contact reflib@nist.gov.

Created May 19, 2008, Updated February 19, 2017