Skip to main content
U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Hydroxyl radical is a significant player in oxidative DNA damage in vivo.

Published

Author(s)

Miral M. Dizdar, Barry Halliwell, Amitav Adhikary, Michael Dingfelder

Abstract

Recent publications have suggested that oxidative DNA damage mediated by hydroxyl radical (.OH) is unimportant in vivo, and that carbonate anion radical (CO3.-) plays the key role. We examine these claims and summarize the evidence that OH does play a key role as an important member of the reactive oxygen species (ROS) in vivo.
Citation
Chemical Society Reviews

Keywords

hydroxyl radical, DNA damage, oxidative stress

Citation

Dizdar, M. , Halliwell, B. , Adhikary, A. and Dingfelder, M. (2021), Hydroxyl radical is a significant player in oxidative DNA damage in vivo., Chemical Society Reviews, [online], https://doi.org/10.1039/D1CS00044F, https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=931588 (Accessed October 26, 2021)
Created June 15, 2021, Updated October 14, 2021