Hydrogels Formed by Endlinking PEG to Dendrimer Crosslink Agents
B D. Viers, Barry J. Bauer, Y A. Akpalu, F Groehn, Da-Wei Liu, G Kim
Hydrogels were formed by endlinking telechelic vinyl sulfone end-functionalized poly(ethylene glycol) with the terminal amines on dendrimers of different generation. These structures are unique in that the dendrimer crosslink sites were very large, and thus very amenable to characterization by TEM and small angle SAXS. The position of SAXS correlation peaks are sensitive swelling conditions (changing temperature, addition of acid or dendrimer complexing salts, dry crystalline networks.) This corroborates a finding that the equilibrium swelling may be changed by changing pH, with the greatest swelling occurring when the pH-4 and the dendrimer amines are charged and repulsive. This suggests that these materials may be used as Asmart gels@ for delivery applications.
American Chemical Society; Division of Polymer Chemistry, Meeting | | | American Chemical Society (ACS)
March 1, 2000
dendrimers, gels, hydrogels, pH sensitive gels, SAXS TEM, smart gels
, Bauer, B.
, Akpalu, Y.
, Groehn, F.
, Liu, D.
and Kim, G.
Hydrogels Formed by Endlinking PEG to Dendrimer Crosslink Agents, American Chemical Society; Division of Polymer Chemistry, Meeting | | | American Chemical Society (ACS)
(Accessed December 1, 2023)