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Hydrogels Formed by Endlinking PEG to Dendrimer Crosslink Agents

Published

Author(s)

B D. Viers, Barry J. Bauer, Y A. Akpalu, F Groehn, Da-Wei Liu, G Kim

Abstract

Hydrogels were formed by endlinking telechelic vinyl sulfone end-functionalized poly(ethylene glycol) with the terminal amines on dendrimers of different generation. These structures are unique in that the dendrimer crosslink sites were very large, and thus very amenable to characterization by TEM and small angle SAXS. The position of SAXS correlation peaks are sensitive swelling conditions (changing temperature, addition of acid or dendrimer complexing salts, dry crystalline networks.) This corroborates a finding that the equilibrium swelling may be changed by changing pH, with the greatest swelling occurring when the pH-4 and the dendrimer amines are charged and repulsive. This suggests that these materials may be used as Asmart gels@ for delivery applications.
Proceedings Title
American Chemical Society; Division of Polymer Chemistry, Meeting | | | American Chemical Society (ACS)
Volume
41
Issue
No. 1
Conference Dates
March 1, 2000
Conference Title
Polymer Preprints

Keywords

dendrimers, gels, hydrogels, pH sensitive gels, SAXS TEM, smart gels

Citation

Viers, B. , Bauer, B. , Akpalu, Y. , Groehn, F. , Liu, D. and Kim, G. (2000), Hydrogels Formed by Endlinking PEG to Dendrimer Crosslink Agents, American Chemical Society; Division of Polymer Chemistry, Meeting | | | American Chemical Society (ACS) (Accessed December 1, 2023)
Created March 1, 2000, Updated February 19, 2017