NOTICE: Due to a lapse in annual appropriations, most of this website is not being updated. Learn more.
Form submissions will still be accepted but will not receive responses at this time. Sections of this site for programs using non-appropriated funds (such as NVLAP) or those that are excepted from the shutdown (such as CHIPS and NVD) will continue to be updated.
An official website of the United States government
Here’s how you know
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
Hydrodynamic Fractionation of Finite Size Nano Gold Clusters
Published
Author(s)
De-Hao D. Tsai, Tae Joon Cho, Frank W. DelRio, Julian S. Taurozzi, Michael R. Zachariah, Vincent A. Hackley
Abstract
We demonstrate a high resolution in situ experimental method for performing simultaneous size-classification and characterization of functional nanoscale gold clusters (NGCs) based on asymmetric-flow field flow fractionation (AFFF). Field emission scanning electron microscopy, atomic force microscopy, multi-angle light scattering (MALS), and in situ ultraviolet-visible optical spectroscopy provide complementary data and imagery confirming the cluster state (i.e., dimer, trimer, tetramer), packing structure, and purity of fractionated populations. An orthogonal analysis of NGC size distributions is obtained using an electrospray-differential mobility analyzer (ES-DMA). A linear correlation exists between the normalized MALS intensity (measured during AFFF elution) and the corresponding number concentration (measured by ES-DMA), establishing the capacity for AFFF to quantify the absolute number concentration of NGCs. The results and corresponding methodology summarized here provide proof of concept for general applications involving the formation, isolation and in situ analysis of both functional and adventitious nanoparticle clusters of finite size.
Tsai, D.
, Cho, T.
, DelRio, F.
, Taurozzi, J.
, Zachariah, M.
and Hackley, V.
(2011),
Hydrodynamic Fractionation of Finite Size Nano Gold Clusters, Journal of the American Chemical Society
(Accessed October 1, 2025)