High-Sensitivity Coherent Anti-Stokes Raman Scattering Microscopy With Two Tightly Synchronized Picosecond Lasers
E Potma, D J. Jones, J X. Cheng, X. Xie, Jun Ye
We demonstrate a significant improvement in signal-to-noise ratio in coherent anti stokes Raman Scattering (CARS) spectroscopy/microscopy, using two highly synchronized picosecond Ti: sapphire lasers. A temporal jitter between the pulse trains from the two independent commercial lasers is reduced from a few picoseconds to difference of} 21 fs, maintained over several hours. The tight synchronization brings the fluctuation of the CARS signal down to the shot-noise limit, leading to enhanced cARS vibrational images of living cells and polymer beads.
, Jones, D.
, Cheng, J.
, Xie, X.
and Ye, J.
High-Sensitivity Coherent Anti-Stokes Raman Scattering Microscopy With Two Tightly Synchronized Picosecond Lasers, Optics Letters
(Accessed December 6, 2023)