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High-Sensitivity Coherent Anti-Stokes Raman Scattering Microscopy With Two Tightly Synchronized Picosecond Lasers

Published

Author(s)

E Potma, D J. Jones, J X. Cheng, X. Xie, Jun Ye

Abstract

We demonstrate a significant improvement in signal-to-noise ratio in coherent anti stokes Raman Scattering (CARS) spectroscopy/microscopy, using two highly synchronized picosecond Ti: sapphire lasers. A temporal jitter between the pulse trains from the two independent commercial lasers is reduced from a few picoseconds to difference of} 21 fs, maintained over several hours. The tight synchronization brings the fluctuation of the CARS signal down to the shot-noise limit, leading to enhanced cARS vibrational images of living cells and polymer beads.
Citation
Optics Letters
Volume
27
Issue
No. 13

Keywords

biological imaging, coherent anti-Stokes Raman scattering (C

Citation

Potma, E. , Jones, D. , Cheng, J. , Xie, X. and Ye, J. (2002), High-Sensitivity Coherent Anti-Stokes Raman Scattering Microscopy With Two Tightly Synchronized Picosecond Lasers, Optics Letters (Accessed June 14, 2024)

Issues

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Created June 30, 2002, Updated October 12, 2021