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Harmonization of LC-MS/MS protein assays

Published

Author(s)

Alan L. Rockwood, Mark Lowenthal, Cory Bystrom

Abstract

Harmonization of diagnostic test results is fundamental to the effective use of laboratory testing in the diagnosis, treatment and monitoring of disease. Formal approaches to harmonization and standardization provide a rigorous and high quality Roadmap to this end, though the formal harmonization process can be long and complex. In the meantime, more informal approaches to harmonization can provide a useful pathway to improved harmonization in the short term. Factors relevant to harmonization are discussed with particular attention to protein assays employing LC- MS/MS. Published formal and informal harmonization projects are provided as examples, including lessons drawn from these projects.
Citation
Clinics in Laboratory Medicine

Keywords

LC-MS/MS, protein, harmonization, standardization

Citation

Rockwood, A. , Lowenthal, M. and Bystrom, C. (2018), Harmonization of LC-MS/MS protein assays, Clinics in Laboratory Medicine, [online], https://doi.org/10.1016/j.cll.2018.05.004, https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=925783 (Accessed June 5, 2023)
Created September 24, 2018, Updated October 13, 2022