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Harmonization of diagnostic test results is fundamental to the effective use of laboratory testing in the diagnosis, treatment and monitoring of disease. Formal approaches to harmonization and standardization provide a rigorous and high quality Roadmap to this end, though the formal harmonization process can be long and complex. In the meantime, more informal approaches to harmonization can provide a useful pathway to improved harmonization in the short term. Factors relevant to harmonization are discussed with particular attention to protein assays employing LC- MS/MS. Published formal and informal harmonization projects are provided as examples, including lessons drawn from these projects.
Rockwood, A.
, Lowenthal, M.
and Bystrom, C.
(2018),
Harmonization of LC-MS/MS protein assays, Clinics in Laboratory Medicine, [online], https://doi.org/10.1016/j.cll.2018.05.004, https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=925783
(Accessed October 9, 2025)