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Harmonization of LC-MS/MS protein assays



Alan L. Rockwood, Mark Lowenthal, Cory Bystrom


Harmonization of diagnostic test results is fundamental to the effective use of laboratory testing in the diagnosis, treatment and monitoring of disease. Formal approaches to harmonization and standardization provide a rigorous and high quality Roadmap to this end, though the formal harmonization process can be long and complex. In the meantime, more informal approaches to harmonization can provide a useful pathway to improved harmonization in the short term. Factors relevant to harmonization are discussed with particular attention to protein assays employing LC- MS/MS. Published formal and informal harmonization projects are provided as examples, including lessons drawn from these projects.
Clinics in Laboratory Medicine


LC-MS/MS, protein, harmonization, standardization


Rockwood, A. , Lowenthal, M. and Bystrom, C. (2018), Harmonization of LC-MS/MS protein assays, Clinics in Laboratory Medicine, [online],, (Accessed June 20, 2024)


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Created September 24, 2018, Updated October 13, 2022