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Formation of Macropores in Calcium Phosphate Cements Through the Use of Mannitol Crystals

Published

Author(s)

Milenko Markovic, Shozo Takagi, Laurence C. Chow

Abstract

Mannitol crystals with sizes ranging from {nearly equal to} 100 m to {nearly equal to} 400 m were mixed with calcium phosphate cement (CPC) powders that contained equimolar amounts of tetracalcium phosphate and dicalcium phosphate anhydrous. CPC-mannitol mixtures with mass fractions of (a) 0 % and (b) 10 % mannitol were mixed with cement liquid (1 mol/L Na2HPO4 solution) at powder-to-liquid ratio (P/L) of 4 g/mL. The hardening times for the two mannitol-containing cements were (a) 5.3 0.3 and (b) 5.5 0.5 (n = 5). The cement pastes were packed into sample molds with an applied pressure of {nearly equal to} 2 MPa. Samples were removed from molds 4 h later and placed in water for 20 h causing complete dissolution of the mannitol and formation of macropores in the shapes of the mannitol crystals. Properties of the 24-h cement samples are as follows: Densities of dried samples were (a) 2.05 0.03 g/cm3 and (b) 1.83 0.04 g/cm3 and (b) (1.83 0.04) g/cm3 (n=8). Macroporosities were (a) 0% and (b) (10.9 1.17) % (n = 8), and microporosities were (a) (34.3 1.0) % and (b) (30.6 0.6)% (n = 8). Diametral tensile strengths (DTS) were (a) (11.8 1.5) Mpa and (b) (7.6 0.9) Mpa (n - 8). Additional CPC-mannitol samples were prepared with P/L = 10 g/mL under a pressure of {nearly equal to} 660 MPA. The DTS of these samples were (a') (20.6 1.5) Mpa and (b') (13.8 1.2) Mpa (n=3).
Proceedings Title
Proceedings of the 13th International Symposium on Ceramics in Medicine; Bioceramics 13
Conference Dates
November 22-26, 2000
Conference Location
Bologna, IT
Conference Title
International Symposium on Ceramic Materials and Components for Engines

Keywords

calcium phosphate cement, hardening time, macropores, mannitol, porosity, strength

Citation

Markovic, M. , Takagi, S. and Chow, L. (2001), Formation of Macropores in Calcium Phosphate Cements Through the Use of Mannitol Crystals, Proceedings of the 13th International Symposium on Ceramics in Medicine; Bioceramics 13, Bologna, IT (Accessed May 21, 2024)

Issues

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Created January 1, 2001, Updated February 17, 2017