Skip to main content
U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Formalizing ISA-95 Level 3 Control with Smart Manufacturing System Models



Leon F. McGinnis


Achieving the vision of "smart manufacturing and "Industrie 4.0" requires building on successes in computational control of processes to create generic approaches for management of manufacturing operations, or smart manufacturing operations management (SMOM). The approach to SMOM presented in this report generalizes the modeling framework of ISA-95 with a reference model for discrete event logistics systems (DELS) that identifies five generic operations management decisions. This report applies it in a computational model of a large-scale, highly-automated central fill pharmacy that is the basis for a simulation testbed enabling convenient experimentation with operations management policies and decision algorithms.
Grant/Contract Reports (NISTGCR) - 19-022
Report Number


McGinnis, L. (2019), Formalizing ISA-95 Level 3 Control with Smart Manufacturing System Models, Grant/Contract Reports (NISTGCR), National Institute of Standards and Technology, Gaithersburg, MD, [online], (Accessed June 18, 2024)


If you have any questions about this publication or are having problems accessing it, please contact

Created December 23, 2019, Updated December 27, 2019