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Fatty Acid Modified Dendrimers in Bulk and Solution: Single Chain Neutron Scattering from Dendrimer Core and Fatty Acid Shell

Published

Author(s)

A Ramzi, Barry J. Bauer, R L. Scherrenberg, P Froehling, J Joosten, Eric J. Amis

Abstract

Small angle neutron scattering (SANS) has been applied to extract the single-chain form factors of the fatty acid (FA) and the dendrimer components in bulk and dilute solution of fatty acid modified poly(propylene imine) dendrimers (Astramol ). The fatty acid chains were covalently or ionically linked to the end groups of two generations, G3 and G5. Bulk samples were prepared under contrast match conditions of mixtures of dendrimer-h/FA-h and dendrimer-h/FA-d to obtain the form factor of the fatty acid components. The solutions were prepared with deuterated fatty acid modified dendrimers in decalin solvent using the contrast match technique. Mixtures of decalin-h and decalin-d were used to match either the dendrimer or FA components. The dendrimer core of both G3 and G5 appears collapsed, without the incorporation of a significant amount of the solvent. The G3 FA portion has a size closer to that of the bulk than that of a collapsed FA shell. The G5 dendrimer has the opposite trend.
Citation
Macromolecules
Volume
32
Issue
No. 15

Keywords

contrast match, dendrimer, fatty acid, PAMAM, radius of gyration

Citation

Ramzi, A. , Bauer, B. , Scherrenberg, R. , Froehling, P. , Joosten, J. and Amis, E. (1999), Fatty Acid Modified Dendrimers in Bulk and Solution: Single Chain Neutron Scattering from Dendrimer Core and Fatty Acid Shell, Macromolecules, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=851529 (Accessed May 19, 2024)

Issues

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Created July 1, 1999, Updated February 17, 2017