Skip to main content
U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Evaluation of Oral Fluid Testing Devices



Lorna T. Sniegoski, Jocelyn L. Prendergast, Michael J. Welch, Alim A. Fatah, M Gackstetter, R. Q. Thompson


Several point-of-collection (POC) devices for detection of drugs of abuse in oral fluid were studied. The ability of the devices to meet the manufacturers' claims and their practical application to detection of drugs of abuse at low concentrations in oral fluid were evaluated. Human saliva fortified with known quantities of cocaine, phencyclidine (PCP), codeine, morphine, amphetamine, methamphetamine, and (±)-11-nor-9-carboxy-∆9-tetrahydrocannabinol (carboxy-THC), was used in the analysis. Each device was also tested for cross-reactivity with a number of common orally administered, over the counter medications, as well as substances which could be expected to occur in human saliva. In general, the POC devices performed close to their specifications, with a few exceptions. In some cases, the design of the device could make interpretation of the results unreliable or uncertain.
NIST Interagency/Internal Report (NISTIR) - 7585
Report Number


Analytical Chemistry, Drugs, Drugs of abuse, Oral fluid, or commonly, Saliva, Point of Collection Devices, testing and evaluation


Sniegoski, L. , Prendergast, J. , Welch, M. , Fatah, A. , Gackstetter, M. and Thompson, R. (2009), Evaluation of Oral Fluid Testing Devices, NIST Interagency/Internal Report (NISTIR), National Institute of Standards and Technology, Gaithersburg, MD, [online], (Accessed July 21, 2024)


If you have any questions about this publication or are having problems accessing it, please contact

Created March 31, 2009, Updated October 12, 2021