Reyes-Hernandez, D.
(2012),
Enabling Long-Term Dielectrophoretic Actuation for Cell Manipulation and Analysis in Microfluidic Biochips, PRIME, Pacific RIM Meeting on Electrochemical and Solid-State Science, Honolulu, HI
(Accessed October 10, 2024)
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Enabling Long-Term Dielectrophoretic Actuation for Cell Manipulation and Analysis in Microfluidic Biochips
Published
Author(s)
Abstract
An approach that combines not only the cell manipulation capabilities of dielectrophoresis (DEP), but also the conditions to promote appropriate cell function during long-term experiments is presented. The integration of a hybrid cell adhesive material (hCAM) with the trapping forces of positive DEP have demonstrated that after DEP trapping and anchorage on the hCAM cells can be differentiated into neuron-like cells after more than a week in the microfluidic system. This approach has also shown promise in the development of a multilayer microfluidic device, where cells can be trapped on opposite sides of a permeable polyester (PET) membrane that separates two channels running perpendicular to each other. Within these devices cells can be exposed to the specific microenvironments required for appropriate cell co-culture conditions. This system can be used for studies such as cell-cell communication, cell migration and many others.Proceedings Title
PRIME, Pacific RIM Meeting on Electrochemical and Solid-State Science
Conference Dates
October 7-12, 2012
Conference Location
Honolulu, HI
Conference Title
Electrochemical Society 222nd Meeting
Pub Type
Conferences
Citation
Issues
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Created October 7, 2012, Updated February 19, 2017