Structural properties of polymeric scaffolds for bone tissue engineering play key role in directing osteogenesis. These properties depend on the chemical nature and the fabrication process of biomaterial. There are many protocols for fabricating scaffolds for bone tissue engineering applications which afford control over scaffold topology. In addition, much work has demonstrated that cell differentiation is sensitive to topology at sizes ranging from nano- to micro- to macroscale1. Thus, we have investigated the effect of different scaffold topologies on differentiation of human bone marrow stromal cells (hBMSCs).
Conference Dates: December 5-7, 2010
Conference Location: Orlando, FL
Conference Title: TERMIS
Pub Type: Conferences
tissue engineering, polymer scaffold, stem cell, cell differentiation, bone, osteogenesis