Effect of a Low-Fluoride-Content, Two-Component Rinse on Fluoride Uptake and on De-and Remineralization of Enamel Lesions: An In Vitro Study

Published

June 1, 2001

Author(s)

Shozo Takagi, H Liao, Laurence C. Chow

Abstract

The effect of calcium (Ca) concentrations and added ethanol on fluoride (F) depositions by experimental two-component rinses, each consisting of a Ca-containing and an F-containing component, was evaluated in an in vitro system. Among the tested rinses, a 3 mmol/I F two-component rinse with 200 mmol/I Ca and a 10 % v/v ethanol was found to produce the greatest F deposition relative to the F concentration in the rinse. Specifically, this rinse produced an F deposition that was about 7 times greater than a conventional 13.2-mmol/I sodium fluoride (NaF) rinse. In a second experiment, an in vitro pH cycling model was used to evaluate the potential anti-caries effects of 4 rinses: (1) placebo rinse (no F), (2) 13.2-mmol/I NaF rinse, (3) 52.6-mmol/I NaF rinse, and (4) the 3-mmol/I F two-component rinse in a 7-day in vitro pH cycling model. The changes in lesion mineral contents, delta (δZ), as assessed by quantitative microoradiographic measurements, were as follows (mean standard deviation, n = 10]: (1) 72.5 10.2 m , (2) 43.4 5.6 m. These results showed that the 3-mmol/I F two-component rinse produced the same (p>0.05) protection against demineralization as did the 13.2-mmol/I NaF rinse which had 4 times the fluoride content. The results suggest that it is possible to formulate an effective low-F two-component rinse.

Citation

Caries Research

Volume

35

Issue

3

Pub Type

Journals

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Keywords

calcium fluoride, enamel, fluoride, fluoride rinse, in vitro pH cyclic model, mineralization, sodiumhexafluorosilicate

Citation

Takagi, S. , Liao, H. and Chow, L. (2001), Effect of a Low-Fluoride-Content, Two-Component Rinse on Fluoride Uptake and on De-and Remineralization of Enamel Lesions: An In Vitro Study, Caries Research, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=851757 (Accessed October 27, 2025)