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Effect of 3D Hydogel Scaffold Modulus and Topology on Human Bone Marrow Stromal Cell Fate

Published

Author(s)

Kaushik Chatterjee, Sheng Lin-Gibson, Sapun Parekh, Nicole M. Moore, Marcus T. Cicerone, marian F. young, Carl Simon Jr.

Abstract

There is growing recognition that cells can sense and respond to the physical cues from their environment, such as stiffness, mechanical loading and topology. Physical properties of the matrix can direct cellular response and are critical in the design of scaffolds for tissue engineering. In this work we examined the effect of matrix modulus on differentiation of human bone marrow stromal cells (hBMSCs) encapsulated within three-dimensional (3D) photo-polymerizable polyethylene glycol (PEG) hydrogels. Further, to investigate the topological effects of the hydrogel scaffolds on cellular differentiation we studied the response of hBMSCs on the gel surface (2D) and those encapsulated within the hydrogel (3D).
Proceedings Title
American Chemical Society
Conference Dates
August 22-26, 2010
Conference Location
boston, MA, US

Keywords

hydrogel, scaffold, tissue engineering, stem cell

Citation

Chatterjee, K. , Lin-Gibson, S. , Parekh, S. , Moore, N. , Cicerone, M. , Young, M. and Simon Jr., C. (2010), Effect of 3D Hydogel Scaffold Modulus and Topology on Human Bone Marrow Stromal Cell Fate, American Chemical Society, boston, MA, US, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=905363 (Accessed May 17, 2022)
Created August 31, 2010, Updated October 12, 2021