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Double-integrating-sphere system at the National Institute of Standards and Technology in support of measurement standards for the determination of optical properties of tissue-mimicking phantoms

Published

Author(s)

Paul Lemaillet, Jeeseong C. Hwang, David W. Allen

Abstract

There is a need for a common reference point that will allow for the comparison of the optical properties of tissue mimicking phantoms. This paper provides a brief review of the methods that have been used to measure tissue mimicking phantoms. The review provides a contextual backdrop to our approach. Here,wealso report on the establishment of a standardized double integrating sphere- based platform to measure absorption and reduced scattering coefficients of tissue-mimicking biomedical phantoms. The platform implements a user-friendly graphical user interface in which variations of experimental configurations and model-based analysis are implemented to compute the coefficients based on amodified inverse adding-doubling algorithm allowing a complete uncertainty evaluation. Repeatability and validation of the measurement results on solid phantoms are demonstrated under the variation of sample configurations, polarization angles of the incident light, and a comparison with the manufacturer's results. We envision that our measurement platform with further in-depth analysis of the associated uncertainties will enable NIST-traceable calibration and validation of biomedical devices involving measurements of tissue optical properties.
Citation
Journal of Biomedical Optics
Volume
20
Issue
12

Keywords

tissue optical property, biomedical optics standard, integrating sphere, tissue-mimicking phantom, tissue optical scattering

Citation

Lemaillet, P. , Hwang, J. and Allen, D. (2015), Double-integrating-sphere system at the National Institute of Standards and Technology in support of measurement standards for the determination of optical properties of tissue-mimicking phantoms, Journal of Biomedical Optics, [online], https://doi.org/10.1117/1.JBO.20.12.121310 (Accessed July 13, 2024)

Issues

If you have any questions about this publication or are having problems accessing it, please contact reflib@nist.gov.

Created October 26, 2015, Updated October 12, 2021