Dispersion Stabilization of Silver Nanoparticles in Synthetic Lung Fluid Studied under In-Situ Conditions

Published

August 23, 2010

Author(s)

Robert I. MacCuspie, Andrew J. Allen, Vincent A. Hackley

Abstract

The dispersion stabilization of silver nanoparticles in synthetic lung fluid is studied systematically to determine the key ingredients for colloidal stabilization. A variety of in-situ techniques are used, including dynamic light scattering, UV-Vis spectroscopy, atomic force microscopy, and small angle x-ray scattering. The stabilization as a result of coating silver nanoparticles with each ingredient of the synthetic lung fluid is observed in a variety of sodium chloride concentrations. It was observed that silver nanoparticles continue to absorb BSA protein from solution as salt is titrated in until a maximum coating is achieved near physiological conditions. Further, the BSA was observed to be the key source of colloidal stabilization of all the ingredients at these concentrations. This work also demonstrates the applicability of synthetic lung fluid to providing stable dispersions for a variety of engineered nanomaterials.

Citation

Nanotoxicology

Volume

5

Issue

2

Pub Type

Journals

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Keywords

AgNPs, BSA, Silver Nanoparticles, Nanoparticle dispersion protocol, SAXS flow cell

Citation

MacCuspie, R. , Allen, A. and Hackley, V. (2010), Dispersion Stabilization of Silver Nanoparticles in Synthetic Lung Fluid Studied under In-Situ Conditions, Nanotoxicology, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=903694 (Accessed October 10, 2025)