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Determination of Perfluorinated Alkyl Acid Concentrations in Biological Standard Reference Materials



Jessica L. Reiner, Jennifer M. Lynch, Michele M. Schantz, Steven O'Connell, Craig M. Butt, Scott Mabury, Jeff Small, Amila De Silva, Derek Muir, Amy D. Delinsky, Mark J. Strynar, Andrew B. Lindstrom, William K. Reagen, Michelle Malinsky, Sandra Schafer, Christiaan Kwadijk


Standard Reference Materials (SRMs) are homogeneous, well-characterized materials that are used to validate measurements and improve the quality of analytical data. The National Institute of Standards and Technology (NIST) has a wide range of SRMs that have values assigned for legacy organic pollutants. These SRMs can serve as target materials for method development and measurement for contaminants of emerging concern. Since inter-laboratory comparison studies have shown considerable disagreements when measuring perfluoroalkyl acids (PFAAs), future analytical measurements will benefit from the characterization of PFAAs in SRMs. NIST, in collaboration with multiple groups, has been measuring concentrations of PFAAs in a variety of SRMs. Here we report on levels of PFAAs and perfluorooctane sulfonamide (PFOSA) determined by the inter-laboratory participants in four SRMs: fish tissue (two materials), bovine liver, and mussel tissue. We also report concentrations for three in-house quality control materials: beluga whale liver, pygmy sperm whale liver, and white-sided dolphin liver. Measurements in SRMs show an array of PFAAs, with perfluorooctane sulfonate (PFOS) being the most frequently detected. Reference and information values are reported for PFAAs measured in these biological SRMs.
Analytical and Bioanalytical Chemistry


Perfluoroalkyl acids, Standard Reference Materials, Fish tissue, Bovine liver, Mussel tissue, Intercomparison exercise


Reiner, J. , Lynch, J. , Schantz, M. , O'Connell, S. , Butt, C. , Mabury, S. , Small, J. , De, A. , Muir, D. , Delinsky, A. , Strynar, M. , Lindstrom, A. , Reagen, W. , Malinsky, M. , Schafer, S. and Kwadijk, C. (2012), Determination of Perfluorinated Alkyl Acid Concentrations in Biological Standard Reference Materials, Analytical and Bioanalytical Chemistry, [online], (Accessed May 23, 2024)


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Created April 4, 2012, Updated November 10, 2018