Hong, L.
, Jain, N.
, Cheng, X.
, Bernal, A.
, Tyagi, M.
and Smith, J.
(2016),
Determination of Functional Collective Motions in a Protein at Atomic Resolution using Coherent Neutron Scattering, Science Advances, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=921815
(Accessed April 19, 2024)
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Determination of Functional Collective Motions in a Protein at Atomic Resolution using Coherent Neutron Scattering
Published
Author(s)
Liang Hong, NItin Jain, Xiaolin Cheng, Ana Bernal, , Jeremy C. Smith
Abstract
Protein function often depends on global, collective internal motions. However, the simultaneous quantitative experimental determination of the forms, amplitudes and timescale of these motions has remained elusive. Here, we demonstrate that a complete description of these large-scale dynamic modes can be obtained using coherent neutron scattering experiments on perdeuterated samples. Using this approach, a microscopic relationship between the structure, dynamics and function in a protein, cytochrome P450cam, is established. The approach developed here should be of general applicability to protein systems.Citation
Science Advances
Volume
2
Issue
10
Pub Type
Journals
Download Paper
Keywords
Protein dynamics, neutron scattering
Citation
Created October 13, 2016, Updated October 12, 2021