Skip to main content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Delivery of Fluorescent Probes Using Iron Oxide Particles as Carriers Enables In Vivo Labeling of Migrating Neural Precursors for MRI and Optical Imaging



James P. Sumner, Richard Conroy, Eric Shapiro, John M. Moreland, Alan P. Koretsky


Iron oxide particles are becoming an important contrast agent for magnetic resonance imaging (MRI) cell tracking studies. Simultaneous delivery of fluorescence indicators with the particles to individual cells offers the possibility of correlating optical and MRI. In this work, it was demonstrated that micron-sized iron oxide particles (MPIOs) can be used as a carrier to deliver fluorescent probes to cells in culture as well as to migrating neural progenitors in vivo. Migrating progenitors were tracked with MRI and easily identified by histology because of the fluorescent probe. These data suggest that using MPIOs to deliver fluorescent probes should make it possible to combine MRI and optical imaging for in vivo cell tracking.
Journal of Biomedical Optics


cell tracking, fluorescent probes, micron sized iron oxide particles, MPIO, MRI
Created November 1, 2007, Updated February 19, 2017