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Controlled Encapsulation of a Hydrophilic Drug Simulant in Nano-Liposomes Using Continuous Flow Microfluidics

Published

Author(s)

Andreas Jahn, Joseph E. Reiner, Wyatt N. Vreeland, Don DeVoe, Laurie E. Locascio, Michael Gaitan

Abstract

A new method to tailor the size and size distribution of nanometer scale liposomes and control loading of liposomes with a model drug in a continuous-flow microfluidic design is presented. Size and size dispersion are determined with tandem Asymmetric Flow Field Flow Fractionation (AF4) and Multi-Angle Laser Light Scattering (MALLS). Fluorescence Correlation Spectroscopy (FCS) combined with Fluorescence Cumulant Analyis (FCA) allow for determining the number of encapsulated molecules [1]. Results show that this system allows for control of loading efficiency as well as minimization of encapsulant consumption.
Proceedings Title
11th Annual Nano Science and Technology Institute (NSTI) Nanotech 2008
Conference Dates
June 1-5, 2008
Conference Location
Boston, MA

Keywords

liposomes, encapsulation, fluorescence spectroscopy, hydrodynamic focusing, microfluidics

Citation

Jahn, A. , Reiner, J. , Vreeland, W. , DeVoe, D. , Locascio, L. and Gaitan, M. (2008), Controlled Encapsulation of a Hydrophilic Drug Simulant in Nano-Liposomes Using Continuous Flow Microfluidics, 11th Annual Nano Science and Technology Institute (NSTI) Nanotech 2008, Boston, MA, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=32987 (Accessed July 3, 2022)
Created June 4, 2008, Updated February 19, 2017