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Confidence Intervals for Treatment Effect from Restricted Maximum Likelihood



Andrew L. Rukhin


Confidence intervals for the treatment effect in random effects meta-analysis model obtained from Harville-Jeske-Kenward-Roger approach are obtained in explicit form. They are compared to some other intervals commonly used in collaborative studies with a small number of participants possibly with heterogeneous, study-specific variances. Monte Carlo simulation experiments recommend the latter intervals.
Computational Statistics


Fisher information, Heteroscedasticity, Interlaboratory study, Random effects model, Restricted likelihood.


Rukhin, A. (2012), Confidence Intervals for Treatment Effect from Restricted Maximum Likelihood, Computational Statistics, [online], (Accessed June 21, 2024)


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Created February 21, 2012, Updated January 27, 2020