Compatibility of Sorbitol-Containing Polyesters. Part I. Synthesis, Surface Analysis and Cell Response in Vitro

Published

August 1, 2004

Author(s)

Ying Mei, A Kumar, W Gao, R Gross, S B. Kennedy, N Washburn, Eric J. Amis, John T. Elliott

Abstract

A series of sorbitol-containing polyesters were synthesized via a one-pot lipase-catalyzed condensation polymerization. Thin films were prepared by spin coating on silicon wafers and surfaces were analyzed by tapping mode AFM and contact angle measurements. Surface morphologies and surface energies across the series of polyester films, including a PCL control were nearly indistinguishable. Biocompatibility of the sorbitol-containing polyester series was evaluated against a PCL control by measuring cell spreading and proliferation of a mouse fibroblast 3T3 cell line in vitro. Results confirmed that the sorbitol-containing polyester surfaces elicited cell behavior similar to the PCL control. These results establish the sorbitol-containing polyester series as a promising material for tissue engineering research and development.

Citation

Biomaterials

Volume

25

Issue

No. 18

Pub Type

Journals

Keywords

biocompatibility, fibroblast, functional polymer, population distribution

Citation

Mei, Y. , Kumar, A. , Gao, W. , Gross, R. , Kennedy, S. , Washburn, N. , Amis, E. and Elliott, J. (2004), Compatibility of Sorbitol-Containing Polyesters. Part I. Synthesis, Surface Analysis and Cell Response in Vitro, Biomaterials (Accessed May 5, 2024)