J C. Meredith, A P. Smith,
Combinatorial methods of drug discovery in pharmaceuticals research are well known and more recent applications have led to the discovery and synthesis of new inorganic materials, catalysts, and organic polymers. Polymeric coatings play an important role in many industrial applications, such as automotive, electrical, aerospace industries where their stability and integrity is of fundamental importance. Recently, we have developed combinatorial and high throughput methods for rapid measurements of properties of polymer coatings, such as phase separation and film dewetting. The results are validated against traditional one-sample measurements and existing physical models. A recent initiative in the Polymers Division at NIST aims at extending combinatorial methods for characterizing biocompatibility of polymeric biomaterials, such as controlling cell growth on patterned polymer substrates or scaffolds prepared by polymer blend extrusion methods.
NIST Interagency/Internal Report (NISTIR) - 6552
biocompatible, cell growth, combinatorial, high throughput, pattern, polymer thin films, scaffolds