Combinatorial Methods for Investigations in Polymer Materials Science

Published

April 1, 2002

Author(s)

J C. Meredith, A P. Smith, A J. Crosby, Eric J. Amis, Alamgir Karim

Abstract

Combinatorial methods of drug discovery in pharmaceuticals research are well known and more recent applications have led to the discovery and synthesis of new inorganic materials, catalysts, and organic polymers. Polymeric coatings play an important role in many industrial applications, such as automotive, electrical, aerospace industries where their stability and integrity is of fundamental importance. Recently, we have developed combinatorial and high throughput methods for rapid measurements of properties of polymer coatings, such as phase separation and film dewetting. The results are validated against traditional one-sample measurements and existing physical models. A recent initiative in the Polymers Division at NIST aims at extending combinatorial methods for characterizing biocompatibility of polymeric biomaterials, such as controlling cell growth on patterned polymer substrates or scaffolds prepared by polymer blend extrusion methods.

Citation

NIST Interagency/Internal Report (NISTIR) - 6552

Report Number

6552

Volume

27

Issue

No. 4

NIST Pub Series

NIST Interagency/Internal Report (NISTIR)

Pub Type

NIST Pubs

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Keywords

biocompatible, cell growth, combinatorial, high throughput, pattern, polymer thin films, scaffolds

Citation

Meredith, J. , Smith, A. , Crosby, A. , Amis, E. and Karim, A. (2002), Combinatorial Methods for Investigations in Polymer Materials Science, NIST Interagency/Internal Report (NISTIR), National Institute of Standards and Technology, Gaithersburg, MD, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=851760 (Accessed October 15, 2025)