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Chips and Tips: Modified luer adapters with small dead volume that fit small tubing



Gregory A. Cooksey, glynnis Mattheisen


Luer adapters are convenient tools to rapidly and reversibly connect tubing from fluid reservoirs to microfluidic devices. One problem associated with the use of these adapters is that they trap considerable dead volume (60 ul, in the case of the adapters we chose), which dramatically increases the time required to rinse away one fluid when another fluid is to be delivered down the same line. Another common shortcoming of leur adapters is that they are only available for 1.59 mm (1/16”) and larger inner diameter tubing. We demonstrate how to modify luer adapters to fit almost any size tubing while dramatically reducing the dead fluid volume.
Lab on A Chip


Microfluidic, connectors, quick-connect, tubing


Cooksey, G. and Mattheisen, G. (2010), Chips and Tips: Modified luer adapters with small dead volume that fit small tubing, Lab on A Chip, [online], (Accessed June 15, 2024)


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Created June 28, 2010, Updated February 19, 2017