NOTICE: Due to a lapse in annual appropriations, most of this website is not being updated. Learn more.
Form submissions will still be accepted but will not receive responses at this time. Sections of this site for programs using non-appropriated funds (such as NVLAP) or those that are excepted from the shutdown (such as CHIPS and NVD) will continue to be updated.
An official website of the United States government
Here’s how you know
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
Characterization of NIST Food-Matrix Standard Reference Materials for their Vitamin C Content
Published
Author(s)
Jeanice M. Brown Thomas, James H. Yen, Katherine E. Sharpless
Abstract
The vitamin C concentrations in three food-matrix Standard Reference Materials (SRMs) from the National Institute of Standards and Technology (NIST) have been determined by liquid chromatography (LC) with absorbance detection. These materials (SRM 1549a Whole Milk Powder, SRM 1849a Infant/Adult Nutritional Formula, and SRM 3233 Fortified Breakfast Cereal) have been characterized to support analytical measurements made by food processors that are required to provide information about their products vitamin C content on the labels of products distributed in the United States. The SRMs are primarily intended for use in validating analytical methods for the determination of selected vitamins, elements, fatty acids, and other nutrients in these materials and in similar matrixes. They can also be used for quality assurance in the characterization of test samples or in-house control materials, and for establishing measurement traceability. Relative precision of the LC method used to measure vitamin C in the food-matrix SRMs characterized in this study ranged from 4 % to 7.5 %.
Brown, J.
, Yen, J.
and Sharpless, K.
(2013),
Characterization of NIST Food-Matrix Standard Reference Materials for their Vitamin C Content, Analytical and Bioanalytical Chemistry, [online], https://doi.org/10.1007/s00216-013-6891-4
(Accessed October 10, 2025)