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CCQM–K62: Nutrients in Infant/Adult Formula – Vitamins: Final Report



Katherine E. Sharpless, Catherine A. Rimmer, Karen W. Phinney, Bryant C. Nelson, David L. Duewer, Stephen A. Wise


Key Comparison CCQM-K62 was designed to enable demonstration of the equivalence in capabilities for measurement of vitamins in a food matrix. A milk-based fortified human infant/adult formula was selected as the matrix based upon material availability and relevance. Because vitamins were added to the CCQM-K62 study material in a single form and at levels significantly higher than those that would be naturally occurring in the milk base, the ability of a laboratory to measure the study vitamins is only indicative of a laboratory’s ability to measure vitamins in fortified foods. Target analytes were selected for study because of the ready availability of suitable standard materials and the range of their chemical properties: folic acid (vitamin B9) is a single water-soluble molecular entity that typically occurs at low levels and can be unstable, niacin (vitamin B3) is a single stable molecular entity and is typically present at higher concentrations than the other water-soluble vitamins, vitamin A has multiple molecular forms (including retinol and retinyl palmitate), is fat-soluble and typically occurs at relatively high levels.


ccqm, key comparison, k62, vitamin, infant, formula, folic acid, niacin, retinol, retinyl


Sharpless, K. , Rimmer, C. , Phinney, K. , Nelson, B. , Duewer, D. and Wise, S. (2010), CCQM–K62: Nutrients in Infant/Adult Formula – Vitamins: Final Report, BIPM, [online], (Accessed April 17, 2024)
Created April 24, 2010, Updated February 19, 2017