CCQM-K63.a,b Non-Peptide Hormones in Serum: Cortisol and Progesterone: Final Report

Published

May 30, 2010

Author(s)

Susan Tai, David L. Duewer

Abstract

Hormones are chemical messengers that regulate many life functions. Deviations from normal hormone levels can have serious health consequences. Accurate measurement of hormone levels in serum can be beneficial in diagnosing, monitoring, and treating a number of diseases. Two steroid hormones, cortisol and progesterone, were selected by the Organic Analysis Working Group (OAWG) to evaluate its member Institutes’ measurement capabilities for this important class of measurand. Serum concentrations of cortisol range from 30 ng/mL to 230 ng/mL. Serum concentrations pf progesterone in adult females range from 0.15 ng/mL to 25 ng/mL but can rise to ≈ 230 ng/mL during pregnancy. The ability to measure cortisol is indicative of a laboratory’s ability to measure steroid hormones at concentration levels similar to cortisol. The ability to measure progesterone is indicative of a laboratory’s ability to measure steroid hormones with similar functional groups and concentration levels, such as testosterone.

Citation

Metrologia

Pub Type

Journals

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Keywords

CCQM, key comparison, k63, non-peptide, hormone, cortisol, progesterone

Citation

Tai, S. and Duewer, D. (2010), CCQM-K63.a,b Non-Peptide Hormones in Serum: Cortisol and Progesterone: Final Report, Metrologia, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=905822 (Accessed April 26, 2024)