Assisting Functional Assignment for Hypothetical Heamophilus Influenzae Gene Products Through Structural Genomics

Published

December 1, 2002

Author(s)

G L. Gilliland, Jane E. Ladner, Prasad T. Reddy, A Teplyakov, G Obmolova, M Tordova, O Herzberg, Kap Lim, H. Zhang, K Huang, Z Li, A Tempczyk, W Kajewski, L Parsons, D C. Yeh, J Orban, Edward Eisenstein, J F. Parsons, N Bonander, K E. Fisher, J Toedt, E Melamud, J Moult, N Thanki, A J. Howard

Abstract

The three-dimensional structures of Haemophilus influenzae proteins with completely unknown function are being determined as part of a structural genomics project. This effort is investigating the use of structural information in assisting protein functional assignment. The structures of the hypothetical proteins are being used to guide further studies and narrow the field of such studies for ultimately determining protein function. An outline of the structural genomics methodological approach is provided along with summaries of a number of completed and in progress crystallographic and NMR structure determinations. With more than twenty-five structures determined at this point and with many more in various stages of completion, the results are encouraging in that some level of functional understanding can be deduced from experimentally solved structures. In addition to aiding in functional assignment, this effort is identifying a number of possible new targets for drug development.

Citation

Current Drug Targets

Volume

2 No. 4

Pub Type

Journals

Keywords

haemophilus influenzae, high-throughput crystallography, hypothetical gene products, NMR spectroscopy, protein crystallography, structural geonomics, three-dimensional structures

Citation

Gilliland, G. , Ladner, J. , Reddy, P. , Teplyakov, A. , Obmolova, G. , Tordova, M. , Herzberg, O. , Lim, K. , Zhang, H. , Huang, K. , Li, Z. , Tempczyk, A. , Kajewski, W. , Parsons, L. , Yeh, D. , Orban, J. , Eisenstein, E. , Parsons, J. , Bonander, N. , Fisher, K. , Toedt, J. , Melamud, E. , Moult, J. , Thanki, N. and Howard, A. (2002), Assisting Functional Assignment for Hypothetical Heamophilus Influenzae Gene Products Through Structural Genomics, Current Drug Targets (Accessed April 23, 2024)