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Analysis of UNMWPE Particle Shape Effects on Bioactivity From the Physical Viewpoint of Phagocytosis Process

Published

Author(s)

H. W. Fang, Stephen M. Hsu, J V. Sengers

Abstract

In artifical joint systems, wear particles generated during the life of the replacement have been associated with Osteolysis and prosthetic loosening. The morphology of the wear particles varies according to different articulating geometry, material pairs, and mechanical conditions. Form the viewpoints of phagocytosis of wear particles by macrophage cells, the mechanisms of particles induced bioactivities will vary according to different particle size and shape [1]. Effects of size [2] and shape [3] of UHMWPE particles on biological responses have been investigated. This study applies the biophysical principles to calculate the maximum number of particles that can be phagocytosed for various sizes and shapes of particles. The purpose is to provide explanations of how particle shape influencing the biological responses that have been illustrated in the previous studies [3].
Citation
World Biomaterials Congress

Keywords

bioactivity, particle shape, phagocytic capacity, phagocytosis, UHMWPE, wear particles

Citation

Fang, H. , Hsu, S. and Sengers, J. (2021), Analysis of UNMWPE Particle Shape Effects on Bioactivity From the Physical Viewpoint of Phagocytosis Process, World Biomaterials Congress (Accessed August 18, 2022)
Created October 12, 2021