Skip to main content
U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Analysis of Covalently Cationized Polystyrenes Using Liquid Chromatography and Mass Spectrometry

Published

Author(s)

Z Vakili, Kathleen M. Flynn, Charles M. Guttman, Mark Arnould, H M. Byrd

Abstract

Production of covalently charged polymers of known molecular mass is important in determining the ability of mass spectrometry (MS) to provide exact Molecular mass and molecular mass distribution information of synthetic polymers. Comparison of the mass spectra of polystyrene samples, ionized by both traditional metal cationization and covalent cationization reveals that covalent cationization increases signal-to-noise and provides more reproducible data. Covalently charged products are contaminated with excess reagents and side products and can be difficult to purify by precipitation. Purification is needed before further analysis can be carried out. Liquid chromatography (LC) is a widely used technique for organic separation and purification. MALDI-TOF-MS after LC is important in determining the presence of polymer in fractions collected from a column and provides insight into the separation efficiency.
Proceedings Title
ASMS Conference on Mass Spectrometry and Allied Topics | 52nd | Proceedings of the 52nd ASMS Conference on Mass Spectrometry and Allied Topics | American Society for Mass Spectrometry (ASMS)
Volume
80(5)
Conference Dates
May 23-27, 2005
Conference Location
Nashville, TN
Conference Title
ASMS Conference on Mass Spectrometry

Keywords

liquid chromatography, polymer, purification, separation, synthesis

Citation

Vakili, Z. , Flynn, K. , Guttman, C. , Arnould, M. and Byrd, H. (2004), Analysis of Covalently Cationized Polystyrenes Using Liquid Chromatography and Mass Spectrometry, ASMS Conference on Mass Spectrometry and Allied Topics | 52nd | Proceedings of the 52nd ASMS Conference on Mass Spectrometry and Allied Topics | American Society for Mass Spectrometry (ASMS), Nashville, TN, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=852363 (Accessed April 14, 2024)
Created January 1, 2004, Updated February 17, 2017