U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

PUBLICATIONS

3.4 kb Mitochondrial Genome Deletion Serves as a Surrogate Predictive Biomarker for Prostate Cancer in Histopathologically Benign Biopsy Cores

Published

Author(s)

Ryan L. Parr, Rajiv Dhir, J P. Jakupciak, Brian Reguly, William Montelpare, Gabriel D. Dakubo

Abstract

Recently, we described a 3.4kb mitochondrial genome deletion having significance for identifying both malignant and benign prostate tissues (p<0.0001). Moreover, this biomarker was present in normal appearing tissue in close proximity to tumor, indicating a field cancerization effect. Here we report 4 case studies (3 malignant, 1 benign) suggesting that this field effect may occur in advance of tumorigenesis, or alternatively, identify the presence of a small tumor focus/foci which are difficult to detect with single, or even multiple sextant biopsy procedures.
Citation
Journal of Molecular Diagnostics
Pub Type
Journals

Keywords

cancer, case histories, mitochondria, prediction

Citation

Parr, R. , Dhir, R. , Jakupciak, J. , Reguly, B. , Montelpare, W. and Dakubo, G. (2021), 3.4 kb Mitochondrial Genome Deletion Serves as a Surrogate Predictive Biomarker for Prostate Cancer in Histopathologically Benign Biopsy Cores, Journal of Molecular Diagnostics (Accessed December 14, 2024)

Issues

If you have any questions about this publication or are having problems accessing it, please contact reflib@nist.gov.

Created October 12, 2021