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3.4 kb Mitochondrial Genome Deletion Serves as a Surrogate Predictive Biomarker for Prostate Cancer in Histopathologically Benign Biopsy Cores

Published

Author(s)

Ryan L. Parr, Rajiv Dhir, J P. Jakupciak, Brian Reguly, William Montelpare, Gabriel D. Dakubo

Abstract

Recently, we described a 3.4kb mitochondrial genome deletion having significance for identifying both malignant and benign prostate tissues (p<0.0001). Moreover, this biomarker was present in normal appearing tissue in close proximity to tumor, indicating a field cancerization effect. Here we report 4 case studies (3 malignant, 1 benign) suggesting that this field effect may occur in advance of tumorigenesis, or alternatively, identify the presence of a small tumor focus/foci which are difficult to detect with single, or even multiple sextant biopsy procedures.
Citation
Journal of Molecular Diagnostics

Keywords

cancer, case histories, mitochondria, prediction

Citation

Parr, R. , Dhir, R. , Jakupciak, J. , Reguly, B. , Montelpare, W. and Dakubo, G. (2021), 3.4 kb Mitochondrial Genome Deletion Serves as a Surrogate Predictive Biomarker for Prostate Cancer in Histopathologically Benign Biopsy Cores, Journal of Molecular Diagnostics (Accessed March 4, 2024)
Created October 12, 2021