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Tyler Laird (Fed)

Bioinformatician / Computational Biologist

Tyler Laird is a bioinformatician within the Complex Microbial Systems Group at NIST. Broadly, his research focuses on assessing and developing metagenomic Next Generation Sequencing (mNGS) workflows and databases for biosurveillance. He employs a variety of computational software (e.g. Nextflow, Python, R) across cloud (AWS) and high-performance computing (HPC) environments and also aims to advance data management best practices and rigorous traceability in bioinformatics.


Some of his current efforts at NIST include: generating datasets to assess baseline sequence screening as part of NIST's Biosecurity for Synthetic Nucleic Acid Sequences program, advancing mNGS methods for sterility testing as a working group lead in the RMTM Consortium, and developing NGS-based assays to ensure the safety of Animal Cells, Tissues, and Cell- and Tissue-Based Products (ACTPs). 

Awards

2026 MML Science Data Management and Capabilities Accolade for timely production of a NIST test dataset for demonstrating screening of Sequences of Concern by synthetic nucleic acid producers

Publications

NIST 2025 Rapid Microbial Testing Methods Workshop Report

Author(s)
Jason Kralj, Kirsten Parratt, Tyler Laird, Stephanie Servetas, Nancy Lin, Dawn Henke, Scott Jackson
In 2020, the National Institute of Standards and Technology (NIST)-led Rapid Microbial Testing Methods (RMTM) Consortium was established to develop standards...

Inter-tool analysis of a NIST dataset for assessing baseline nucleic acid sequence screening

Author(s)
Tyler Laird, Kevin Flyangolts, Craig Bartling, Bryan Gemler, Jacob Beal, Tom Mitchell, Steven T. Murphy, Jens Berlips, Leonard Foner, Ryan Doughty, Felix Qunitana, Michael Nute, Todd J. Treangen, Gene D. Godbold, Krista Ternus, Tessa Alexanian, Nicole Wheeler, Samuel Forry
Nucleic acid synthesis is a dual-use technology that can benefit fields such as biology, medicine, and information storage. However, synthetic nucleic acids...

Data and Software Publications

Created June 5, 2024, Updated October 2, 2026
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