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Robert Brinson

Research Chemist

Robert applies biophysical measurements to define structure and dynamics of nucleic acids, proteins, and glycoproteins with a specific focus on biotherapeutics. In particular, Robert seeks to push the limits of NMR methodologies to define the critical quality attribute of higher order structure for protein drug products. Robert also applies chemometric analyses to 2D NMR spectra.

Robert received his Ph.D. in chemistry from Wake Forest University in 2005 where he studied the photo-activation of caged biocides under the direction of Paul Jones. He then entered the field of structural biology as a NIH/NIST NRC postdoctoral fellow under John Marino (NIST) and Stuart Le Grice (NCI). Under their direction, Robert performed high resolution NMR studies on purine rich RNA/DNA hybrids derived from HIV-1 and Saccharomyces cerevisiae long-terminal repeat (LTR)-retrotransposon Ty3.

Awards

2016, Department of Commerce Silver Award

Publications

Structural Insights into DNA-Stabilized Silver Clusters

Author(s)
Danielle Schultz, Robert G. Brinson, Fahriye N. Sari, Jeffrey A. Fagan, Christina Bergonzo, Nancy J. Lin, Joy P. Dunkers
The structure and dynamics of Ag complexes derived from single stranded DNA (ssDNA) is less understood than their double stranded (dsDNA) counterparts despite

Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics

Author(s)
Robert G. Brinson, John P. Marino, Frank Delaglio, Luke W. Arbogast, Ryan M. Evans, Anthony J. Kearsley, Yves Aubin, Gregory Pierens, Xinying Jia, David Keizer, Jonas Stahle, Goran Widmalm, Chad Lawrence, Patrick Reardon, John Cort, Koichi Kato, Stuart Parnham, Andreas Blomgren, Torgny Rundlof, Kang Chen, David Keire, Thea Suter-Stahel, Gerhard Wider, Donna Baldisseri, Julie Wu, Mats Wikstrom, Medhi Mobli
Of the top ten drugs on the global market in 2016, seven of them are biologics with a combined market value of over US$60 billion. Moreover, around 2,800
Created June 18, 2019