Official websites use .gov
A .gov website belongs to an official government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
Kyle Tynan (Fed)
Kyle came to NIST in 2024 as a National Research Council Postdoctoral Fellow. He earned his B.S. degree in Chemical Engineering from the University of South Carolina. He subsequently completed his Ph.D. in Chemical Engineering from Carnegie Mellon University, where he developed novel analytical techniques for the rapid assessment of critical quality attributes in mRNA and mRNA-lipid nanoparticles. He developed a new method for assessing mRNA length, integrity, and purity and a new technique to determine both encapsulation efficiency and PEGylation percentage in mRNA lipid nanoparticles.
Currently, his research centers on creating a robust multi-attribute method to detect and quantify impurities in in vitro transcribed mRNA. These impurities include double-stranded RNA (dsRNA), residual DNA templates, and unincorporated nucleotides, all of which can impact the safety and efficacy of mRNA-based products. In parallel, he is working to develop a computational model that predicts the likelihood of mRNA aggregation based on nucleotide sequence characteristics, aiming to improve formulation stability and manufacturing efficiency.
