Skip to main content
U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Kyle Anderson (Fed)

Research Chemist

Kyle Anderson is a NIST Research Chemist and Project Leader for HDX-MS for Biopharmaceutical Analysis and also an Associate Research Professor at the University of Maryland Institute for Bioscience and Biotechnology Research (IBBR). In addition to using hydrogen/deuterium exchange mass spectrometry (HDX-MS) to characterize the structural dynamics of biopharmaceuticals, he is active in developing and promoting adoption of state-of-the-art methods for HDX-MS to ensure quality and accelerate development of biotherapeutics and biosimilars. He received the U.S. Department of Commerce Silver Medal in 2021 and Bronze Medal in 2023. He is a member of the International Society of HDX-MS, the Editorial Advisory Board for the Journal of the American Society for Mass Spectrometry, the American Society for Mass Spectrometry, and the CCQM Protein Analysis Working Group.

H/D exchange mass spectrometry (HDX-MS) for biopharmaceutical analysis

Postdoctoral Research Opportunities

National Research Council Postdoctoral Research Associate Program at NIST: Rolling application deadlines are Feb 1 and Aug 1. US citizens only. $74,950 (2022) annual salary plus benefits. Contact Kyle Anderson before applying. View Job Posting

Positions for non-US citizens: Contact Kyle Anderson directly.

Research Objectives:

  • Characterize protein-based vaccines in formulation by HDX-MS
  • Characterize drug-protein interactions by HDX-MS
  • Adopt internal H/D exchange reporters and materials for NIST standard reference materials to improve reproducibility and harmonization of HDX-MS
  • Develop HDX-MS for assessments of dynamical comparability among innovator and candidate biosimilar drugs
  • Improve HDX-MS technology


2021 U.S. Department of Commerce Silver Medal
2023 U.S. Department of Commerce Bronze Medal
2019 NIST MML Outreach Accolade
2015 National Research Council Postdoctoral Research Associateship


Interlaboratory Studies using the NISTmAb to Advance Biopharmaceutical Structural Analytics

Katharina Yandrofski, Trina Mouchahoir, M. Lorna De Leoz, David L. Duewer, Jeffrey W. Hudgens, Kyle Anderson, Luke Arbogast, Frank Delaglio, Robert Brinson, John Marino, Karen W. Phinney, Michael J. Tarlov, John E. Schiel
Biopharmaceuticals such as monoclonal antibodies are required to be rigorously characterized using a wide range of analytical methods. Various material
Created May 31, 2018, Updated October 25, 2023