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Kyle Anderson (Fed)

Research Chemist

Kyle Anderson is a Research Chemist and Project Leader for H/D exchange mass spectrometry (HDX-MS) for biopharmaceutical analysis at NIST and also has an appointment as a Research Scientist at the University of Maryland Institute for Bioscience and Biotechnology Research (IBBR). In addition to using hydrogen/deuterium exchange mass spectrometry (HDX-MS) to characterize the structural dynamics of biopharmaceuticals, he is active in developing and promoting adoption of state-of-the-art methods for HDX-MS to ensure quality and accelerate development of biotherapeutics and biosimilars.

Research Objectives:

  • Characterize protein-based vaccines in formulation by HDX-MS
  • Characterize drug-protein interactions by HDX-MS
  • Adopt internal H/D exchange reporters and materials for NIST standard reference materials to improve reproducibility and harmonization of HDX-MS
  • Develop HDX-MS for assessments of dynamical comparability among innovator and candidate biosimilar drugs
  • Improve HDX-MS technology

Postdoctoral Research Opportunities

National Research Council Postdoctoral Research Associate Program at NIST: Rolling application deadlines are Feb 1 and Aug 1. US citizens only. $82,764 (2024) annual salary plus benefits. Contact Kyle Anderson before applying. View Job Posting

Positions for non-US citizens: Contact Kyle Anderson directly.

Committees & Activities :

Editorial Advisory Board, Journal of the American Society for Mass Spectrometry (2024-present)
CIPM CCQM Protein Analysis Working Group member (2023-present)
American Society for Mass Spec. Membership, Diversity, and Inclusion Committee (2024-present)
Washington Chromatography Discussion Group, President (2017–2020, 2021–2022), VP (2016-2017), Secretary (2015–2016, 2020–2021), Board (2022–2023)
NIIMBL Subject Matter Expert
American Society for Mass Spectrometry (2022-present)
CASSS D.C. Area Discussion Group (2015-present)
International Society for HDX-MS (2019 – present)
Washington-Baltimore Mass Spectrometry Discussion Group (2016-present)


U.S. Department of Commerce Silver Medal, 2021
U.S. Department of Commerce Bronze Medal, 2023
ASMS Emerging Investigator, 2023
NIST MML Outreach Accolade, 2019
National Research Council Postdoctoral Research Associateship, 2015
Outstanding Science Student Award, Pennsylvania State Univ., 2007
MG James Ursano Scholarship, 2006, 2007, 2008, 2009
Chancellors Scholarship Award, Pennsylvania State University, 2006, 2007
Commonwealth of Pennsylvania Grant, 2006, 2007


Interlaboratory Studies using the NISTmAb to Advance Biopharmaceutical Structural Analytics

Katharina Yandrofski, Trina Mouchahoir, M. Lorna De Leoz, David L. Duewer, Jeffrey W. Hudgens, Kyle Anderson, Luke Arbogast, Frank Delaglio, Robert Brinson, John Marino, Karen W. Phinney, Michael J. Tarlov, John E. Schiel
Biopharmaceuticals such as monoclonal antibodies are required to be rigorously characterized using a wide range of analytical methods. Various material
Created May 31, 2018, Updated February 15, 2024