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Kyle Anderson (Fed)
Research Chemist
Kyle W. Anderson is the Project Leader for H/D exchange mass spectrometry (HDX-MS) for biopharmaceutical analysis at NIST. He is also an Associate Research Professor at the Institute for Bioscience and Biotechnology Research (IBBR), a joint institute of the University of Maryland and NIST. In addition to using hydrogen/deuterium exchange mass spectrometry (HDX-MS) to characterize the structural dynamics of biopharmaceuticals, he is active in developing and promoting adoption of state-of-the-art methods, instrumentation, and software for HDX-MS to ensure quality and accelerate development of biotherapeutics and biosimilars.
Research Objectives:
- Characterize protein-based vaccines in formulation by HDX-MS
- Characterize drug-protein interactions by HDX-MS
- Adopt internal H/D exchange reporters and materials for NIST standard reference materials to improve reproducibility and harmonization of HDX-MS
- Develop HDX-MS for assessments of dynamical comparability among innovator and candidate biosimilar drugs
- Improve HDX-MS technology
Postdoctoral Research Opportunities
National Research Council Postdoctoral Research Associate Program at NIST: Rolling application deadlines are Feb 1 and Aug 1. US citizens only. $82,764 (2024) annual salary plus benefits. Contact Kyle Anderson before applying. View Job Posting
Positions for non-US citizens: Contact Kyle Anderson directly.
Committees & Activities :
Editorial Advisory Board, Journal of the American Society for Mass Spectrometry (2024-present)
CIPM CCQM Protein Analysis Working Group member (2023-present)
Washington Chromatography Discussion Group, President (2017–2020, 2021–2022), VP (2016-2017), Secretary (2015–2016, 2020–2021), Board (2022–2023)
NIIMBL Subject Matter Expert
American Society for Mass Spectrometry (2017-present)
CASSS D.C. Area Discussion Group (2015-present)
International Society for HDX-MS (2019 – present)
Washington-Baltimore Mass Spectrometry Discussion Group (2016-present)
Awards
Presidential Early Career Award for Scientists and Engineers (PECASE), 2022
U.S. Department of Commerce Silver Medal, 2021
U.S. Department of Commerce Bronze Medal, 2023
ASMS Emerging Investigator, 2023
NIST MML Outreach Accolade, 2019
National Research Council Postdoctoral Research Associateship, 2015