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John E Schiel (Fed)

Dr. Schiel is a research chemist in the NIST Biomolecular Measurement Division and on detail to the Advanced Manufacturing National Program Office (AMNPO) as the Technical Program Manager for NIIMBL, the National Institute for Innovation in Manufacturing Biopharmaceuticals (the NIST-sponsored Manufacturing USA institute). He received his B.S. and Ph.D. degrees in chemistry from the University of Nebraska-Lincoln. 

Dr. Schiel coordinates the development of Reference Materials that support the biomanufacturing industry, including the recombinant IgG1κ NIST monoclonal antibody Reference Material 8671 (NISTmAb).  He also leads an analytical research team developing innovative approaches toward production/characterization of next generation biotherapeutics (e.g. viral vectors, cell therapy products, and vaccines) and de-risking of innovative technologies for lifecycle appropriate implementation and regulatory assimilation. 

He is an author of over 30 publications, an editor of the ACS book series “State-of-the-Art and Emerging Technologies for Therapeutic Monoclonal Antibody Characterization”, and recipient of numerous Awards including the Arthur S. Flemming Award, Department of Commerce Gold Medal, ACS Division of Analytical Chemistry Fellowship, Bioanalysis Young Investigator Award, and UNL Early Achiever Award.

As the NIIMBL Technical Program Manager, he provides technical leadership to manage the NIIMBL-funded American Rescue Plan projects covering coronavirus response research, collaborates with NIST lab programs on opportunities to leverage NIIMBL, and advises the institute on technology and workforce development projects.



  • Arthur S. Flemming Award, 2021
  • United States Department of Commerce Gold Medal, 2017
  • University of Nebraska Early Achiever Award, 2014
  • Featured “Young Investigator in Analytical and Bioanalytical Science”, 2012 (ABC, 403, 2279-2289)
  • NIST Sigma Xi Most Outstanding Poster Award, 2010 and 2011
  • Sigma Xi Outstanding Graduate Award, 2009
  • Bioanalysis Young Investigator Award, 2009 (Bioanalysis, 1, 17-18)
  • HPLC Inc. Student Travel Award, 2008
  • Phi Lambda Upsilon Travel Grant, 2008
  • University of Nebraska Graduate Fellowship, 2008
  • Fred W. Upson Grant-in-Aid, 2008
  • Othmer Graduate Fellowship, 2004-2008
  • American Chemical Society Division of Analytical Chemistry Fellowship, 2007 (Anal. Chem., 79, 385)
  • Phi Lambda Upsilon Travel Grant, 2007
  • Howard Hadley Scholarship, 2003
  • Viola Jelenik Scholarship, 2003
  • Sandoz Scholarship, 2002
  • Chancellor’s Award, 2002
  • Sandoz Scholarship, 2001
  • M. Merwin Simmons Memorial Scholarship, 2001
  • James Canfield Scholarship, 2000
  • Chancellors Award, 1999


Interlaboratory Attribute Analytics Metrics from the MAM Consortium Round Robin Study

Trina Mouchahoir, John E. Schiel, Rich Rogers, N. Alan Heckert, Benjamin Place, Aaron Ammerman, Xiaoxiao Li, Tom Robinson, Brian Schmidt, Chris M. Chumsae, Xinbi Li, Anton V. Manuilov, Bo Yan, Gregory O. Staples, Da Ren, Alexander J. Veach, Dongdong Wang, Wael Yared, Zoran Sosic, Yan Wang, Li Zang, Anthony M. Leone, Peiran Liu, Richard Ludwig, Li Tao, Wei Wu, Ahmet Cansizoglu, Andrew Hanneman, Greg W. Adams, Irina Perdivara, Hunter Walker, Margo Wilson, Arnd Brandenburg, Nick DeGraan-Weber, Stefano Gotta, Joe Shambaugh, Melissa Alvarez, X. Christopher Yu, Li Cao, Chun Shao, Andrew Mahan, Hirsh Nanda, Kristen Nields, Nancy Nightlinger, Ben Niu, Jihong Wang, Wei Xu, Gabriella Leo, Nunzio Sepe, Yan-Hui Liu, Bhumit A. Patel, Douglas Richardson, Yi Wang, Daniela Tizabi, Oleg V. Borisov, Yali Lu, Ernest L. Maynard, Albrecht Gruhler, Kim F. Haselmann, Thomas N. Krogh, Carsten P. Sönksen, Simon Letarte, Sean Shen, Kristin Boggio, Keith Johnson, Wenqin Ni, Himakshi Patel, David Ripley, Jason C. Rouse, Ying Zhang, Carly Daniels, Andrew Dawdy, Olga Friese, Thomas W. Powers, Justin B. Sperry, Josh Woods, Eric Carlson, K. Ilker Sen, St John Skilton, Michelle Busch, Anders Lund, Martha Stapels, Xu Guo, Sibylle Heidelberger, Harini Kaluarachchi, Sean McCarthy, John Kim, Jing Zhen, Ying Zhou, Sarah Rogstad, Xiaoshi Wang, Jing Fang, Weibin Chen, Ying Qing Yu, John G. Hoogerheide, Rebecca Scott, Hua Yuan
The multi-attribute method (MAM) was conceived as a single assay to potentially replace multiple single-attribute assays that have long been used in process

Interlaboratory Studies using the NISTmAb to Advance Biopharmaceutical Structural Analytics

Katharina Yandrofski, Trina Mouchahoir, M. Lorna De Leoz, David L. Duewer, Jeffrey W. Hudgens, Kyle Anderson, Luke Arbogast, Frank Delaglio, Robert Brinson, John Marino, Karen W. Phinney, Michael J. Tarlov, John E. Schiel
Biopharmaceuticals such as monoclonal antibodies are required to be rigorously characterized using a wide range of analytical methods. Various material
Created September 24, 2019, Updated December 8, 2022