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Jeffrey W. Hudgens (Assoc)

Research Chemist

Current Investigations

  • H/D exchange mass spectrometry (HDX-MS) for biopharmaceutical analysis
  • Dynamics of ligand-membrane protein and ligand-transmembrane protein interactions
  • Comparability of innovator and biosimilar drugs measured with HDX-MS
  • Improvement of measurement and quality assurance protocols for HDX-MS
  • Covalent and noncovalent bonding interactions of biological drugs (and other biological materials) with surfaces and nanoparticles
  • High-performance mass spectrometry

NOTE: Dr. Hudgens has an NRC Postdoctoral Opportunity in Research involving Hydrogen/deuterium (HDX) exchange mass spectrometry (Qualified candidates should contact Dr. Hudgens for more information). The next deadlines for submission of applications are 1 FEB 2022 and 1 AUG 2022.


Dr. Jeffrey W. Hudgens' research investigates the precision of hydrogen-deuterium exchange mass spectrometry (HDX-MS) and its application to the measurement of protein-ligand and glycoprotein-ligand interactions, the dynamical structures of mAbs, lipid-protein complexes, and transmembrane protein interactions. Dr. Hudgens received his B.S. in Chemistry from Miami University (Ohio) and his Ph.D. in Physical Chemistry from the University of Illinois at Urbana. He was awarded a National Research Council Postdoctoral Associateship at the Naval Research Laboratory. He remained at NRL for another seven years as a staff scientist, where he pioneered research concerning resonance enhanced multiphoton ionization (REMPI) spectroscopy of free radicals, the fundamentals of infrared multiphoton dissociation (IRMPD) and inverse radiationless processes. In 1984 he moved to the National Bureau of Standards (now NIST). At NIST Dr. Hudgens inaugurated early research that employed cavity ringdown spectroscopy as a tool for the study of chemical kinetics. He invented evanescent-wave cavity ringdown spectroscopy of liquid films. With mass spectrometry he has conducted numerous studies, which determined the structure of a metal-sugar complex and deduced reaction networks that form nearly monodisperse gold:phosphine nanoclusters. Dr. Hudgens' 138+ scientific publications and two patents span many disciplines including chemical dynamics, chemical kinetics, chemical thermodynamics, inorganic biochemistry, laser chemistry, optical spectroscopy, mass spectrometry, and nanochemistry. Dr. Hudgens is a Fellow of the American Physical Society.  

Selected Honors and Awards

  • Department of Commerce Silver Medal for developing and promoting adoption of methods to determine protein structure that increase patient access to life-saving biosimilar drugs, 2021
  • Chemical Science and Technology Laboratory (CSTL) Technical Achievement Award for the Invention of Evanescent Wave Cavity Ringdown Spectroscopy, 1998
  • Fellow of the American Physical Society, 1995
  • National Bureau of Standards Bronze Medal for for pioneering non-linear spectroscopy of free radicals, 1987
  • Naval Research Laboratory Invention Award, 1983 (for a method in mass spectrometry)

Conferences and Workshops Organized

  • Organizer and Co-chairman of the Third, Fourth, and  Fifth International Conference on Chemical Kinetics that convened in July of 1997, 2001, 2005 at NIST in Gaithersburg, MD.
  • Organizing committee member of the "Workshop on Combustion Simulation Databases for Real Transportation Fuels, 2003". Subsequently, Dr. Hudgens acted as the editor and as a co-author of the 2003 NIST workshop report.
  • Organizer of workshops in 2002 and 2003 that brought together US and Hungarian scientists from leading scientific institutions enabling establishment of a Web-accessible database of critically evaluated thermodynamic data for free radicals. These workshops were sponsored by the US-Hungarian Research Council and the International Union of Pure and Applied Chemistry (IUPAC).

Complete List of Publications


Interlaboratory Studies using the NISTmAb to Advance Biopharmaceutical Structural Analytics

Katharina Yandrofski, Trina Mouchahoir, M. Lorna De Leoz, David L. Duewer, Jeffrey W. Hudgens, Kyle Anderson, Luke Arbogast, Frank Delaglio, Robert Brinson, John Marino, Karen W. Phinney, Michael J. Tarlov, John E. Schiel
Biopharmaceuticals such as monoclonal antibodies are required to be rigorously characterized using a wide range of analytical methods. Various material
Created October 9, 2019, Updated December 8, 2022